{"id":67,"date":"2022-01-18T10:26:14","date_gmt":"2022-01-18T10:26:14","guid":{"rendered":"http:\/\/www.lfos4glaucoma.gr\/?page_id=67"},"modified":"2022-01-20T13:33:26","modified_gmt":"2022-01-20T13:33:26","slug":"stoxoi","status":"publish","type":"page","link":"https:\/\/www.lfos4glaucoma.gr\/index.php\/stoxoi\/","title":{"rendered":"\u0391\u039d\u03a4\u0399\u039a\u0395\u0399\u039c\u0395\u039d\u039f &#038; \u03a3\u03a4\u039f\u03a7\u039f\u0399"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.14.6&#8243; background_enable_color=&#8221;off&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#2ea3f2&#8243; background_color_gradient_end=&#8221;#2e6df4&#8243; background_color_gradient_direction=&#8221;330deg&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_header title=&#8221;\u0391\u039d\u03a4\u0399\u039a\u0395\u0399\u039c\u0395\u039d\u039f \u039a\u0391\u0399 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\u03ba\u03b1\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b8\u03c5\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03cc \u03b2\u03ac\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2<\/p>\n<p class=\"p3\">\u03a4\u03bf \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03be\u03bf\u03c5\u03b8\u03b5\u03bd\u03c9\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03cc\u03c3\u03bf\u03c5\u03c2 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\u03ba\u03b1\u03c4\u03ac\u03b8\u03bb\u03b9\u03c8\u03b7. \u039f\u03b9 \u03ba\u03cd\u03c1\u03b9\u03bf\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b3\u03bb\u03b1\u03c5\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1 \u03c0\u03af\u03b5\u03c3\u03b7 (IOP), \u03c4\u03b7 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b7\u03bb\u03b9\u03ba\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bf\u03b9\u03ba\u03bf\u03b3\u03b5\u03bd\u03b5\u03b9\u03b1\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03b3\u03bb\u03b1\u03c5\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p3\">\u03a0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1 \u03c0\u03af\u03b5\u03c3\u03b7, \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03b3\u03bb\u03b1\u03c5\u03ba\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03bf\u03c0\u03c4\u03b9\u03ba\u03ae \u03bd\u03b5\u03c5\u03c1\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c8\u03b7\u03bb\u03ae \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1 \u03c0\u03af\u03b5\u03c3\u03b7. \u0397 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ae \u03c0\u03ac\u03b8\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1. \u03a0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b5\u03c2, \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2, \u03c0\u03bf\u03bb\u03c5\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ad\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03bb\u03b1\u03c5\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2. \u039c\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2 <i>(OHTS &#8211; Ocular hypertension treatment study) <\/i>\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac \u226520% \u03bc\u03b5 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03ba\u03b1\u03c4\u03ac ~ 50% \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7.<\/p>\n<p class=\"p3\">\u03a0\u03ad\u03bd\u03c4\u03b5 \u03ba\u03cd\u03c1\u03b9\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03c0\u03b1\u03c1\u03cc\u03bd \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c7\u03c1\u03ae\u03c3\u03b7: \u03b1-\u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03af \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 (\u03b2\u03c1\u03b9\u03bc\u03bf\u03bd\u03b9\u03b4\u03af\u03bd\u03b7), \u03b2-\u03b1\u03b4\u03c1\u03b5\u03bd\u03b5\u03c1\u03b3\u03b9\u03ba\u03bf\u03af \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 (\u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2, \u03c0.\u03c7. \u03c4\u03b9\u03bc\u03bf\u03bb\u03cc\u03bb\u03b7), \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b2\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c5\u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 (\u03c0.\u03c7. \u03b2\u03c1\u03b9\u03bd\u03b6\u03bf\u03bb\u03b1\u03bc\u03af\u03b4\u03b7, \u03b4\u03bf\u03c1\u03b6\u03bf\u03bb\u03b1\u03bc\u03af\u03b4\u03b7), \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03af\u03bd\u03b7\u03c2 (\u03c0.\u03c7. \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7, \u03c4\u03c1\u03b1\u03b2\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7, \u03b2\u03b9\u03bc\u03b1\u03c4\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7). \u03a0\u03b1\u03c1\u03cc\u03bb\u03bf \u03c0\u03bf\u03c5 \u03bf\u03b9 \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b5\u03b9\u03ce\u03c3\u03b5\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03c9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ac \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03c4\u03b1 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03af\u03bd\u03b7\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03ba\u03b5\u03c1\u03b4\u03af\u03c3\u03b5\u03b9 \u03ad\u03b4\u03b1\u03c6\u03bf\u03c2 \u03c9\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03ae \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\">\u03a4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ba\u03b1\u03c4\u03ac \u03c4\u03bf\u03c5 \u03b3\u03bb\u03b1\u03c5\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bc\u03b5\u03b9\u03ce\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1 \u03c0\u03af\u03b5\u03c3\u03b7 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c5\u03b4\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03b3\u03c1\u03bf\u03cd \u03ba\u03b1\u03b9\/\u03ae \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03ba\u03c1\u03bf\u03ae \u03c4\u03bf\u03c5 \u03c5\u03b4\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c5\u03b3\u03c1\u03bf\u03cd. \u0397 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae \u03c0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03bb\u03b1\u03c5\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b5\u03c1\u03bf \u03bd\u03b1 \u03bc\u03b7\u03bd \u03c3\u03c5\u03bc\u03bc\u03bf\u03c1\u03c6\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03cc\u03c3\u03bf \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03b7 \u03c0\u03bf\u03bb\u03c5\u03c0\u03bb\u03bf\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c7\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03bb\u03b7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc \u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c0\u03c1\u03ce\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03bd\u03b5\u03c0\u03ae \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1-\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2, \u03b2-\u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03c1\u03b2\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c5\u03b4\u03c1\u03ac\u03c3\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03af\u03bd\u03b7\u03c2.<\/p>\n<p class=\"p1\">\u03a4\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03b5\u03af \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b3\u03bb\u03b1\u03c5\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03c4\u03b7\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03b5\u03c2 \u03b4\u03c5\u03bd\u03b1\u03c4\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2. \u0397 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \/\u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03b1\u03c0\u03cc \u03c4\u03bf \u03bc\u03b1\u03ba\u03c1\u03bf\u03c0\u03c1\u03cc\u03b8\u03b5\u03c3\u03bc\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03bc\u03b5 \u03c4\u03b7 \u03c3\u03b5\u03b9\u03c1\u03ac \u03c4\u03bf\u03c5 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7<span class=\"Apple-converted-space\">\u00a0 <\/span>\u03c3\u03cd\u03bd\u03b8\u03b5\u03c3\u03b7 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac. \u039f\u03b9 \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ad\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03c4\u03b5\u03c7\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ce\u03bd \u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03b9\u03b1\u03bb\u03cd\u03bc\u03b1\u03c4\u03b1 (62,4%), \u03bf\u03b9 \u03b1\u03bb\u03bf\u03b9\u03c6\u03ad\u03c2 (17,4%) \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03bd\u03b1\u03b9\u03c9\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 (8,7%). \u03a4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03bf\u03c5\u03bd \u03c3\u03c7\u03b5\u03b4\u03cc\u03bd \u03c4\u03bf 90% \u03c4\u03c9\u03bd \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03c9\u03bd \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ce\u03bd \u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a4\u03b1 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03bb\u03cd\u03bc\u03b1\u03c4\u03b1, \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c0\u03c1\u03bf\u03c4\u03b5\u03c1\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03bf\u03cd\u03c2, \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bb\u03ac \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03c3\u03ba\u03b5\u03c5\u03ae, \u03b4\u03b9\u03ae\u03b8\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03c4\u03b5\u03af\u03c1\u03c9\u03c3\u03b7.<\/p>\n<p class=\"p1\">\u0391\u03c0\u03cc \u03c4\u03b1 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03bb\u03cd\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03bf\u03cd\u03c2 \u03b3\u03bb\u03b1\u03c5\u03ba\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03ae\u03c2 \u03b3\u03c9\u03bd\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c5\u03c0\u03ad\u03c1\u03c4\u03b1\u03c3\u03b7\u03c2, \u03b7 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7 \u03b5\u03bd\u03b4\u03b5\u03af\u03ba\u03bd\u03c5\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03ae\u03c2 \u03b3\u03c9\u03bd\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03c4\u03bf\u03bd\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1 \u03c0\u03af\u03b5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03cc \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\">\u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac, \u03b7 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03bf \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03b3\u03bb\u03b1\u03bd\u03b4\u03af\u03bd\u03b7\u03c2 F2\u03b1, \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd prostanoid FP \u03c0\u03bf\u03c5 \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1 \u03c0\u03af\u03b5\u03c3\u03b7 \u03b1\u03c5\u03be\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03ba\u03c1\u03bf\u03ae \u03c4\u03bf\u03c5 \u03c5\u03b4\u03b1\u03c4\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03c5\u03b3\u03c1\u03bf\u03cd. \u0397 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03b1\u03c1\u03c7\u03af\u03b6\u03b5\u03b9 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03ad\u03c3\u03c3\u03b5\u03c1\u03b9\u03c2 \u03ce\u03c1\u03b5\u03c2 \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bc\u03ad\u03b3\u03b9\u03c3\u03c4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc 8-12 \u03ce\u03c1\u03b5\u03c2. \u03a0\u03b1\u03c1\u03ac \u03c4\u03b7\u03bd \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7\u03c2, \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03bf\u03c5\u03c3\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03c7\u03bb\u03c9\u03c1\u03b9\u03bf\u03cd\u03c7\u03bf \u03b2\u03b5\u03bd\u03b6\u03b1\u03bb\u03ba\u03cc\u03bd\u03b9\u03bf \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03cc \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 Xalatan (0.005% \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03bb\u03c5\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 0.02% \u03c7\u03bb\u03c9\u03c1\u03b9\u03bf\u03cd\u03c7\u03bf \u03b2\u03b5\u03bd\u03b6\u03b1\u03bb\u03ba\u03cc\u03bd\u03b9\u03bf). \u03a4\u03bf\u03c0\u03b9\u03ba\u03ad\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03ba\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c0\u03b5\u03c6\u03c5\u03ba\u03cc\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03bf\u03b4\u03b7\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03be\u03b7\u03c1\u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03af\u03b1\u03c2 (DED), \u03c4\u03b7\u03c2 \u03b4\u03b9\u03cc\u03b3\u03ba\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c0\u03b5\u03c6\u03c5\u03ba\u03cc\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b2\u03bb\u03b5\u03c6\u03b1\u03c1\u03af\u03c4\u03b9\u03b4\u03b1\u03c2. \u0397 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03ba\u03b8\u03b5\u03c3\u03b7 \u03c3\u03c4\u03bf \u0392\u0391\u039a \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03ad\u03bc\u03bc\u03b5\u03c3\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b5\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b2\u03b9\u03c9\u03c3\u03b9\u03bc\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03c6\u03c1\u03b1\u03b3\u03bc\u03bf\u03cd. \u03a9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1, \u03b7 \u03b4\u03c5\u03c3\u03c6\u03bf\u03c1\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03b4\u03c5\u03c3\u03b1\u03c1\u03ad\u03c3\u03ba\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ba\u03b1\u03ba\u03ae \u03c3\u03c5\u03bc\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03b1\u03c0\u03bf\u03c4\u03c5\u03c7\u03af\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ac \u03c3\u03b5 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\">\u03a4\u03bf 2011, \u03b5\u03b3\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac Monoprost\u00ae (Laboratoires Th\u00e9a, ClermontFerrand, \u0393\u03b1\u03bb\u03bb\u03af\u03b1) \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u0399\u0399 \u03ba\u03b1\u03b9 \u03c6\u03ac\u03c3\u03b7\u03c2 \u0399\u0399\u0399 \u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03cc\u03c4\u03b9 \u03b7 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03ad\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03cc\u03bc\u03bf\u03b9\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bd\u03ce \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03b1\u03bd\u03b5\u03ba\u03c4\u03ae \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03bf \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03cc \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac. \u03a4\u03bf \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c7\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03b8\u03b7\u03ba\u03b5 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b5\u03c0\u03af\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ce\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03b5\u03c1\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c6\u03b5\u03c6\u03c5\u03ba\u03cc\u03c4\u03b1 \u03c3\u03b5 \u03c3\u03cd\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac.<span class=\"Apple-converted-space\">\u00a0 <\/span>\u039c\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c0\u03ac\u03bd\u03c9 \u03bf \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03cc\u03c2 \u039f\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03a6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd (EMA) \u03b1\u03bd\u03b1\u03b3\u03bd\u03ce\u03c1\u03b9\u03c3\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03b3\u03b9\u03b1 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ac \u03c3\u03ba\u03b5\u03c5\u03ac\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03b1\u03bd\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b5\u03c2 \u03bc\u03b5 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03c7\u03c1\u03b5\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b5\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9\u03c2 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03c9\u03bd \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c0\u03b1\u03b9\u03b4\u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b1 \u03bd\u03b5\u03bf\u03b3\u03bd\u03ac. \u039f EMA \u03c3\u03b1\u03c6\u03ce\u03c2 \u03b5\u03bd\u03b8\u03ac\u03c1\u03c1\u03c5\u03bd\u03b5 \u03c4\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b5\u03c2 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03be\u03bf\u03c5\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ad\u03c2 \u03c3\u03c4\u03b1\u03b3\u03cc\u03bd\u03b5\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac, \u03cc\u03c0\u03bf\u03c4\u03b5 \u03b1\u03c5\u03c4\u03cc \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c6\u03b9\u03ba\u03c4\u03cc.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\">\u03a4\u03bf \u03b5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03ac, Monoprost, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03ba\u03c4\u03b7 \u03bc\u03bf\u03bd\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2.<span class=\"Apple-converted-space\">\u00a0 <\/span>\u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c2 \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd \u03bb\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7\u03bb\u03b9\u03ba\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03be\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03cc\u03c1\u03b1\u03c3\u03b7\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03ba\u03bf\u03bb\u03af\u03b1 \u03c3\u03c4\u03bf \u03c7\u03b5\u03b9\u03c1\u03b9\u03c3\u03bc\u03cc \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ce\u03bd \u03c0\u03b5\u03c1\u03b9\u03b5\u03ba\u03c4\u03ce\u03bd \u03bc\u03bf\u03bd\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2. \u0393\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03bf\u03b9 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b5\u03c2 \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03b9 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03af \u03c0\u03b5\u03c1\u03b9\u03ad\u03ba\u03c4\u03b5\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03bc\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03b1\u03ba\u03ae \u03bc\u03cc\u03bb\u03c5\u03bd\u03c3\u03b7 \u03b1\u03c6\u03cc\u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03bf\u03cd\u03bd.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\">\u03a3\u03c4\u03b1 \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03ad\u03c1\u03b3\u03bf\u03c5 \u03c4\u03bf \u03c0\u03c1\u03bf\u03c2 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\u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd\u03c2 \u03c4\u03b7\u03c2 \u0395\u0395 \u03ad\u03c4\u03c3\u03b9 \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03b5\u03bd\u03c4\u03c1\u03c9\u03b8\u03bf\u03cd\u03bd \u03cc\u03bb\u03b1 \u03c4\u03b1 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03b2\u03bf\u03bb\u03ae \u03c6\u03b1\u03ba\u03ad\u03bb\u03bf\u03c5, \u03b5\u03bd\u03ce \u03c4\u03bf \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd <span class=\"s1\">\u03c0\u03bf\u03c5 \u03b8\u03b1 \u03ba\u03b1\u03c4\u03bf\u03c7\u03c5\u03c1\u03c9\u03b8\u03b5\u03af \u03bc\u03b5 \u03b4\u03af\u03c0\u03bb\u03c9\u03bc\u03b1 \u03b5\u03c5\u03c1\u03b5\u03c3\u03b9\u03c4\u03b5\u03c7\u03bd\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b1\u03c2 \u03c0\u03b1\u03c4\u03ad\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 \u03b8\u03b1 \u03c3\u03c5\u03bc\u03b2\u03ac\u03bb\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03c9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c9\u03c2 \u03b5\u03ba \u03c4\u03bf\u03cd\u03c4\u03bf\u03c5 \u03b8\u03b1 \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03bb\u03bb\u03b7\u03bd\u03b9\u03ba\u03ae\u03c2 \u03bf\u03b9\u03ba\u03bf\u03bd\u03bf\u03bc\u03af\u03b1\u03c2.<\/span><span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p4\">\n<p class=\"p3\"><b>\u03a4\u03bf \u03c5\u03c0\u03b5\u03c1\u03b3\u03b5\u03bd\u03cc\u03c3\u03b7\u03bc\u03bf \u03c3\u03ba\u03b5\u03cd\u03b1\u03c3\u03bc\u03b1 (value added medicine) \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03bf\u03cd \u03b4\u03b9\u03b1\u03bb\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2 \u039b\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd, \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd, \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03ba\u03c4\u03b7 Novelia\u00aePFS <\/b>\u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c8\u03b7\u03bb\u03ae \u03b9\u03ba\u03b1\u03bd\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03cc\u03c3\u03bf\u03bd \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03c3\u03c4\u03b7\u03bd \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03bb\u03b5\u03b9\u03b4\u03af \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ad\u03c2, \u03c3\u03c5\u03bd\u03b5\u03c7\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1. \u03a4\u03bf \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u0395&amp;\u0391 <b>LFOS4Glaucoma<\/b><span class=\"s2\"><b> <\/b><\/span>\u03b2\u03b1\u03c3\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ac\u03c4\u03c9 \u03ac\u03be\u03bf\u03bd\u03b5\u03c2-\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2:<\/p>\n<p class=\"p2\"><b><\/b><\/p>\n<ul class=\"ul1\">\n<li class=\"li5\"><span class=\"s3\"><\/span>\u03c4\u03b7\u03bd \u03c0\u03c1\u03bf-\u03bc\u03bf\u03c1\u03c6\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2 (Preformulation)<\/li>\n<li class=\"li5\"><span class=\"s3\"><\/span>\u03c4\u03bf\u03bd \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03c3\u03cd\u03bc\u03c6\u03c9\u03bd\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03b8\u03bf\u03b4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 Quality by Design (QbD)<\/li>\n<li class=\"li5\"><span class=\"s3\"><\/span>\u03c4\u03b7\u03bd \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 (Core Development)<\/li>\n<li class=\"li5\"><span class=\"s3\"><\/span>\u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c0\u03b9\u03bb\u03bf\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03c4\u03af\u03b4\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03cd\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2<\/li>\n<li class=\"li5\"><span class=\"s3\"><\/span>\u03c4\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03bf\u03c2<\/li>\n<li class=\"li5\"><span class=\"s3\"><\/span>\u03c4\u03bf\u03bd \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 (Scientific advice)<\/li>\n<\/ul>\n<p class=\"p1\">T\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03ad\u03c1\u03b3\u03bf\u03c5 <b>LFOS4Glaucoma<\/b> \u03bc\u03b5 \u03c4\u03b7\u03bd <b>\u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf\u03c5 \u03b4\u03b9\u03b1\u03bb\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2 \u039b\u03b1\u03c4\u03b1\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c4\u03b7\u03c2 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ce\u03bd \u03b4\u03cc\u03c3\u03b5\u03c9\u03bd \u03b5\u03bb\u03b5\u03cd\u03b8\u03b5\u03c1\u03bf \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03ba\u03c4\u03b7 Novelia\u00aePFS<\/b> \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf <b>\u03b1\u03bd\u03b1\u03c0\u03c4\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c3\u03c4\u03b7\u03bd \u0395\u03bb\u03bb\u03ac\u03b4\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03b8\u03ad\u03c3\u03b9\u03bc\u03bf \u03c3\u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae \u0388\u03bd\u03c9\u03c3\u03b7<\/b> \u03b5\u03af\u03bd\u03b1\u03b9:<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<ul class=\"ul1\">\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7<\/b> \u03b4\u03b9\u03b1\u03bb\u03c5\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ae \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03bf\u03af\u03c7\u03c9\u03bd \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ce\u03bd \u03c3\u03ba\u03b5\u03c5\u03b1\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c5\u03c0\u03cc \u03c4\u03b7\u03bd \u03bc\u03bf\u03c1\u03c6\u03ae \u03b4\u03b9\u03b1\u03bb\u03c5\u03bc\u03ac\u03c4\u03c9\u03bd<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03b7 \u03b2\u03b5\u03bb\u03c4\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 <\/b>\u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae, \u03bb\u03cc\u03b3\u03c9 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03c3\u03c5\u03bd\u03c4\u03b7\u03c1\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bc\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2<\/b><span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03b7 \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae<\/b> \u03c3\u03c4\u03b7\u03bd \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03bc\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03c3\u03c5\u03bc\u03bc\u03cc\u03c1\u03c6\u03c9\u03c3\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd<\/li>\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7<\/b> \u03c4\u03b7\u03c2 <b>\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<span class=\"Apple-converted-space\">\u00a0<\/span><\/b><\/li>\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03b7 \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/b><span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03b7 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1<\/b> \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li class=\"li1\"><span class=\"s1\"><\/span><b>\u03c4\u03bf \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c6\u03bf\u03c1\u03ad\u03b1 \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03af\u03b4\u03b9\u03bf \u03c4\u03bf\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae <\/b>\u03b1\u03c6\u03bf\u03cd \u03c4\u03bf \u03ba\u03cc\u03c3\u03c4\u03bf\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03ba\u03c4\u03b5\u03c2 \u03bc\u03bf\u03bd\u03ae\u03c2 \u03b4\u03cc\u03c3\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf<\/li>\n<\/ul>\n<p class=\"p1\">\u03a4\u03bf \u03ad\u03c1\u03b3\u03bf <b>LFOS4Glaucoma<\/b>, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ac\u03c1\u03c1\u03b7\u03ba\u03c4\u03b1 \u03c3\u03c5\u03bd\u03b4\u03b5\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c7\u03b5\u03b9\u03c1\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c7\u03b5\u03b9\u03c1\u03b7\u03c3\u03b9\u03b1\u03ba\u03ad\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03bb\u03ac\u03b4\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b9\u03c2 \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03b5\u03be\u03b5\u03bb\u03af\u03be\u03b5\u03b9\u03c2, \u03c4\u03b1 \u03b5\u03c5\u03c1\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u0388\u03be\u03c5\u03c0\u03bd\u03b7\u03c2 \u0395\u03b9\u03b4\u03af\u03ba\u03b5\u03c5\u03c3\u03b7\u03c2 (RIS3) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03c5\u03b3\u03ba\u03c1\u03b9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03b3\u03c7\u03ce\u03c1\u03b9\u03c9\u03bd \u03c0\u03bb\u03b5\u03bf\u03bd\u03b5\u03ba\u03c4\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd. \u03a4\u03bf \u03ad\u03c1\u03b3\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af <b>\u0391\u03be\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u0395\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u0391\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03ac\u03c4\u03c9\u03bd \u03c4\u03b7\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 RAFARM,<\/b> \u03ba\u03b1\u03b9 \u03b5\u03bd\u03c4\u03ac\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u0388\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c3\u03c4\u03bf\u03bd \u03c4\u03bf\u03bc\u03ad\u03b1 \u03c4\u03c9\u03bd \u03a6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd\u03c4\u03c9\u03bd \u03b4\u03b9\u03cc\u03c4\u03b9 \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd <b>\u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03bd\u03ad\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03bf\u03c1\u03c6\u03ce\u03bd \u03c0\u03c1\u03bf\u03c3\u03c4\u03b9\u03b8\u03ad\u03bc\u03b5\u03bd\u03b7\u03c2 \u03b1\u03be\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b5\u03be\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2<\/b> (<b>\u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b4\u03b5\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03b5\u03af \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03bf \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c3\u03c4\u03b7\u03bd \u0395\u03c5\u03c1\u03ce\u03c0\u03b7<\/b>) <b>\u03b2\u03b1\u03c3\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03c3\u03b5 \u03ae\u03b4\u03b7 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03c3\u03b1 \u03c0\u03b1\u03c4\u03ad\u03bd\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03b5\u03be\u03b5\u03b9\u03b4\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03c3\u03ba\u03b5\u03c5\u03ae \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03c5\u03bd <\/b>\u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ae \u03a3\u03a4\u039f\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bb\u03ac\u03c4\u03c4\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03b5\u03bd\u03b4\u03bf\u03c6\u03b8\u03ac\u03bb\u03bc\u03b9\u03b1\u03c2 \u03c0\u03af\u03b5\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03bf\u03c6\u03b8\u03b1\u03bb\u03bc\u03b9\u03ba\u03ae \u03c5\u03c0\u03b5\u03c1\u03c4\u03bf\u03bd\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b3\u03bb\u03b1\u03cd\u03ba\u03c9\u03bc\u03b1 \u03b1\u03bd\u03bf\u03b9\u03c7\u03c4\u03ae\u03c2 \u03b3\u03c9\u03bd\u03af\u03b1\u03c2<b>.<\/b><\/p>\n<p class=\"p3\"><span class=\"s2\"><b>\u0391\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2<\/b><\/span><span class=\"s2\"><b><\/b><\/span><\/p>\n<p class=\"p1\">[1] Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014 Nov;121(11):2081-90.<\/p>\n<p class=\"p1\">[2] Varma R, Lee PP, Goldberg I, Kotak S. An assessment of the health and economic burdens of glaucoma. Am J Ophthalmol. 2011 Oct;152(4):515-22.<\/p>\n<p class=\"p1\">[3] Traverso CE, Walt JG, Kelly SP, Hommer AH, Bron AM, Denis P, Nordmann JP, Renard JP, Bayer A, Grehn F, Pfeiffer N, Cedrone C, Gandolfi S, Orzalesi N, Nucci C, Rossetti L, Azuara-Blanco A, Bagnis A, Hitchings R, Salmon JF, Bricola G, Buchholz PM, Kotak SV, Katz LM, Siegartel LR, Doyle JJ. Direct costs of glaucoma<span class=\"Apple-converted-space\">\u00a0 <\/span>and severity of the disease: a multinational long term study of resource utilisation in Europe. Br J Ophthalmol. 2005 Oct;89(10):1245-9.<\/p>\n<p class=\"p1\">[4] Coleman AL, Kodjebacheva G. Risk factors for glaucoma needing more attention.<span class=\"Apple-converted-space\">\u00a0 <\/span>Open Ophthalmol J. 2009 Sep 17;3:38-42.<\/p>\n<p class=\"p1\">[5] Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or<span class=\"Apple-converted-space\">\u00a0 <\/span>prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002 Jun;120(6):701-13; discussion 829-30.<\/p>\n<p class=\"p1\">[6] Conlon R, Saheb H, Ahmed II. Glaucoma treatment trends: a review. Can J Ophthalmol. 2017 Feb;52(1):114-124.<\/p>\n<p class=\"p1\">[7] Saettone et al. Ophthalmic emulsions and suspensions. Journal of Toxicology: Cutaneous and Ocular toxicology. 2001, Volume 20: Issue 2-3, pages 183-201.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\">[8] Summary of Product Characteristics Xalatan 50 micrograms\/ml eye drops solution https:\/\/www.medicines.org.uk\/emc\/product\/1616\/smpc<\/p>\n<p class=\"p1\">[9] Baudouin C, Labb\u00e9 A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29(4):312\u2013334.<\/p>\n<p class=\"p1\">[10] Jaenen N, Baudouin C, Pouliquen P, Manni G, Figueiredo A, Zeyen T. Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol. 2007;17(3):341\u2013349.<\/p>\n<p class=\"p1\">[11] Rouland JF, Traverso CE, Stalmans I, et al; T2345 Study Group. Efficacy and safety of preservative-free latanoprost eyedrops, compared with BAK-preserved latanoprost in patients with ocular hypertension or glaucoma. Br J Ophthalmol. 2013;97(2):196\u2013200.<\/p>\n<p class=\"p1\">[12] Summary of product characteristics MONOPOST latanoprost 50 mcg\/ml eye drops, solution in single-dose container https:\/\/www.medicines.org.uk\/emc\/product\/2978\/smpc<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p class=\"p1\">[13] Rouland JF, Traverso CE, Stalmans I, et al; T2345 Study Group. Efficacy and safety of preservative-free latanoprost eyedrops, compared with BAK-preserved latanoprost in patients with ocular hypertension or glaucoma. Br J Ophthalmol. 2013;97(2):196\u2013200.<\/p>\n<p class=\"p1\">[14] Aptel F, Choudhry R, Stalmans I. Preservative-free versus preserved latanoprost eye drops in patients with open-angle glaucoma or ocular hypertension. Curr Med Res Opin. 2016;32(8):1457\u20131463.<\/p>\n<p class=\"p1\">[15] Cucherat M, Stalmans I, Rouland JF. Relative efficacy and safety of preservative-free latanoprost (T2345) for the treatment of open-angle glaucoma and ocular hypertension: an adjusted indirect comparison meta-analysis of randomized clinical trials. J Glaucoma. 2014;23(1):e69\u2013e75.<\/p>\n<p class=\"p1\">[16] EMEA\/622721\/2009<span class=\"Apple-converted-space\">\u00a0 <\/span>EMEA PUBLIC STATEMENT ON ANTIMICROBIAL PRESERVATIVES IN OPHTHALMIC PREPARATIONS FOR HUMAN USE <a href=\"http:\/\/www.techtran.co.jp\/%2520reportd\/emea091208.pdf\"><span class=\"s1\">http:\/\/www.techtran.co.jp\/ reportd\/emea091208.pdf<\/span><\/a><\/p>\n<p class=\"p1\">[17] Novelia eye dropper <a href=\"https:\/\/www.nemera.net\/products\/ophthalmic-novelia-eyedropper\/\">https:\/\/www.nemera.net\/products\/ophthalmic-novelia-eyedropper\/<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>H \u0388\u03c1\u03b5\u03c5\u03bd\u03b1 &amp; \u039a\u03b1\u03b9\u03bd\u03bf\u03c4\u03bf\u03bc\u03af\u03b1 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03bf\u03bd \u03c4\u03bf\u03bc\u03ad\u03b1 \u03c4\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03c1\u03ce\u03c4\u03b5\u03c2, \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03c0\u03c1\u03bf\u03c4\u03b5\u03c1\u03b1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c0\u03b1\u03b3\u03ba\u03bf\u03c3\u03bc\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1\u03c4\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03b6\u03c9\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03bf\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03b6\u03c9\u03ae\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03cc\u03c3\u03b2\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae, \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03b9\u03c4\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1. \u0391\u03bd\u03c4\u03b9\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03bf \u03c4\u03bf\u03c5 \u03ad\u03c1\u03b3\u03bf\u03c5 \u03a0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u0391\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 LFOS4Glaucoma \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b5\u03bd\u03cc\u03c2<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_rtcl_gb_attr":"","footnotes":""},"class_list":["post-67","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.14 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u0391\u039d\u03a4\u0399\u039a\u0395\u0399\u039c\u0395\u039d\u039f &amp; 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